College Football Week 2 Expert Picks, Predictions For Michigan-Oklahoma And More

Will Texas avenge last season's loss to Ohio State? Can Michigan bounce back against Oklahoma after a shocking and controversial near-upset? Which teams will prove that their Week 1 performance wasn't a fluke, but a trend to rely on? 

The college football season rolls on, and Week 2's lineup is looking strong with some big cross-conference games, from Texas-Ohio State to Michigan-Oklahoma to Illinois-Duke and so many more.

So before Week 2 kicks off, we've got some picks of the week, along with answers to those questions and more. We're breaking down our straight-up picks for Week 2 and which matchups to keep a close eye on this weekend.

Let's get into it. 

When: Friday, 8 p.m. ET (FOX)
Where: David Booth Kansas Memorial Stadium, Lawrence, Kansas
Line: Missouri -5.5

RJ Young: Missouri
The Tigers have the better quarterback, and their run game is still rather awesome even without Ahmad Hardy in the backfield.

Laken Litman: Missouri
Mizzou takes down Kansas in an old rivalry game as former Ole Miss quarterback Austin Simmons lights up the Jayhawks with another multi-touchdown performance.

Michael Cohen: Missouri
As a new face in a new place, Missouri quarterback Austin Simmons gave the Tigers plenty to be excited about in Week 1 with four touchdowns and only two incompletions. He keeps it rolling against the Jayhawks. 

Ben Portnoy: Missouri
I'm in on Austin Simmons being a difference maker for the Tigers, even with a depleted run game. Head coach Eli Drinkwitz has largely handled business as a favorite during his tenure, and I think he does it again this week.

When: Saturday, noon ET (FOX)
Where: Michigan Stadium, Ann Arbor, Michigan
Line: Oklahoma -5.5

Young: Oklahoma 
The Sooners have the edge at quarterback, wide receiver and defensive line. This could get ugly for Michigan if Bryce Underwood doesn't show a tremendous leap in development.

Litman: Oklahoma
The biggest question for me is how Michigan quarterback Bryce Underwood will look after last week's near disaster against Western Michigan. You know Oklahoma head coach Brent Venables will put together a defensive game plan that makes it as hard as possible for the young signal-caller to succeed. 

Cohen: Oklahoma
Maybe the Wolverines will bounce back a bit following last week's controversial win over Western Michigan. But the safer bet is that Oklahoma's terrific defense can cause even more problems for Bryce Underwood, whose time as the starter feels like it's dwindling.

Portnoy: Oklahoma
Recency bias has me incredibly down on the Wolverines, but there's nothing I saw in Saturday's win (?) over Western Michigan that makes me think they can beat a team of Oklahoma's caliber. I think the Sooners are a legit dark horse to win the SEC this year, and I love what a healthy John Mateer brings. Give me the Sooners, big.

When: Saturday, noon ET (ESPN)
Where: Boone Pickens Stadium, Stillwater, Oklahoma
Line: Oregon -22.5

Young: Oregon
Oregon is coming off of an embarrassing win, still has one of the best rosters in the sport and is about to play an Oklahoma State team that got beat by Tulsa, the smallest FBS school in the country. Name the number, Ducks.

Litman: Oregon
The Ducks had their "wake-up call" last week vs. Boise State, who could end up being the Group of Six College Football Playoff representative. While Stillwater is a tough place to play, Dan Lanning will have his team ready to go,