Weight regain after obesity drugs tied to higher odds of suicidal thoughts in observational study

This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).

Adults who reported using prescription weight-loss medication in the last year had higher rates of , mental-health counseling, suicidal thoughts and suicide-related behaviors compared to people who did not take the drugs, according to an observational study.

The research, conducted at Asan Medical Center in South Korea, analyzed data from 27,741 adults (10,908 men and 16,833 women).

Of these participants, 846 had been taking prescription medications for weight control during the previous year, while 26,895 did not take them.

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The weight-loss drug users were 1.9 times more likely to experience depression and twice as likely to seek counseling.

They were also 2.7 times more likely to have suicidal thoughts and 1.7 times more likely to make a suicide attempt.

The associations were stronger among those using the medications who gained or regained weight.

"The tendency for depression and suicide-related indicators to increase as after using weight-loss drugs may reflect not only the neuropsychiatric effects of the drugs themselves, but also a complex interplay of psychological and social factors associated with failed weight control," the research team wrote in the study.

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The findings were published in the Korean Journal of Family Practice on Aug. 23.

Bonnie Mitchell, a licensed professional clinical counselor in California, noted that this was an observational, cross-sectional study.

"It shows a correlation between and self-reported mental health symptoms, but it cannot prove causation," she told Fox News Digital. "It does not demonstrate that weight-loss medications directly induce depression or suicidal thoughts."

The data was collected between 2013 and 2022.

"During most of this period, modern GLP-1/GIP receptor agonists used for weight loss (such as high-dose semaglutide/Wegovy or tirzepatide/Zepbound/Mounjaro) were either not yet on the market or had very limited real world uptake in South Korea," Mitchell said.

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"The study sample captures older anti-obesity agents historically prescribed in South Korea during that decade, including phentermine, diethylpropion, phendimetrazine, topiramate and orlistat."

Central nervous system stimulants – including phentermine-based drugs – have been shown to carry risks of anxiety, mood changes and insomnia, the counselor noted.

"The study highlighted a striking sub finding that found users who gained weight despite taking the medication had 4.2 times higher odds of suicidal ideation compared to non-users," Mitchell noted.

Weight regain or perceived "failure" in weight management can trigger profound guilt, shame, helplessness and psychological distress, according to the expert.

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